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M9630250.TXT
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1996-02-27
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Document 0250
DOCN M9630250
TI Cutaneous presentations of lymphoma in human immunodeficiency virus
disease. Predominance of T cell lineage.
DT 9603
AU Kerschmann RL; Berger TG; Weiss LM; Herndier BG; Abrahms KM; Heon V;
Schulze K; Kaplan LD; Resnik SD; LeBoit PE; Department of Pathology,
University of California Medical Center,; San Francisco, USA.
SO Arch Dermatol. 1995 Nov;131(11):1281-8. Unique Identifier : AIDSLINE
MED/96067815
AB BACKGROUND AND DESIGN: Most non-Hodgkin's lymphomas in patients with
human immunodeficiency virus infection are of B-cell lineage. Cutaneous
lymphoma in the human immunodeficiency virus disease has not been
systematically reviewed. We studied 25 patients with both human
immunodeficiency virus infection and cutaneous presentations of
lymphoma, using immunohistochemistry and in situ hybridization for
Epstein-Barr virus. RESULTS: Two groups of patients were discerned: (1)
those with conditions similar to mycosis fungoides or Sezary syndrome
with an indolent course (n = 8) and (2) those with nodules or papules,
greater immunosuppression, a rapid clinical course, and large cell
lymphoma seen on biopsy specimens (n = 17). The epidermotropic lymphomas
were T-cell lineage and CD30-. Thirteen of the large cell lymphomas were
also of the T-cell type, and 71% were CD30+. Epstein-Barr virus was
absent in the epidermotropic lymphomas, but it was present in 73% of the
nonepidermotropic cases. CONCLUSIONS: Two forms of human
immunodeficiency virus-associated cutaneous lymphoma were found:
indolent disease resembling mycosis fungoides or Sezary syndrome and
large cell lymphomas with a poor prognosis, whose cells often had a
CD30+ T-cell phenotype and harbored the Epstein-Barr virus.
DE Adult Human Immunophenotyping Lymphoma, AIDS-Related/*PATHOLOGY
Lymphoma, T-Cell, Cutaneous/*PATHOLOGY Middle Age Mycosis
Fungoides/PATHOLOGY Sezary Syndrome/PATHOLOGY Skin
Neoplasms/*PATHOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).